Charlie starts working as a cab driver to earn some extra money. However, Anthony decides to take advantage of this by coaxing him into taking the longest fare of his life... to Colorado.

Shortly after Charlie and Anthony leave for Colorado, the rest of the team at Rockport Memorial Hospital tries to adapt to some new routines, to fill their absences. Teddy becomes the temporary lead at All Species Dental, while Dave inherits Charlie's caseload of patients.

After deciding to stick around in Colorado for a while, Anthony and Charlie now have to find new jobns while they're out there. Charlie gets hired at the only place that'll take him, at an animal hospital, while Anthony asks his old dentist for a job at his clinic, opting to take a backseat from a leadership role.

Anthony starts seeing animal patients at the practice, which draws the ire of his boss, who is frustrated that he's going against their protocol. In true Anthony fashion, however, he decides to fight for the animals' rights to equal dental care, showing he's more than capable of treating non-human patients.

One day at the vet hospital, Charlie meets a young puppy who comes in for an exam. After getting to know the puppy a little more, Charlie introduces him to Anthony, and through the dog's treatment they start to grow a bond with each other, similar to that of two fathers and their son. This leads to the surprising revelation that the puppy has no home to go back to.

Tension in the hospital is at an all-time high, as a powerful storm surges through Rockport, causing a massive influx of patients to arrive. However, the situation is turned uposide down, and all hell breaks losse, when the building is struck by lighting and the power goes out across the facility. The team must work together to keep themselves calm, help each other out, and navigate the process with as little casualties as possible.

After Kevin doscovers Anthony has gone back to Colorado for a while, he toys with the idea of paying him a visit. However, he also struggles to decide whether he wants to confront his past as well. as he considers speaking tto Anthony's mother for the first time since they separated over sixteen years prior.

One day at All Species, Teddy doesn't arrive to work on time, causing the team to grow 6concerned for him when they are unable to reach them. However, Teddy's son informs them that he's still at home, and has gone into hibernation... in the middle of summer. The team has to race to find out why, and wake Teddy up, beofree his deep sleep becomes permanent.

An older cat comes in to Anthony's dental office one day for a cleaning and cavity filling, and the two start to grow a friendship with one another, leading them to hang out when Anthony has time off. However, they try to keep their relationship a secret... until Charlie finds out, and completely disapproves.

Charlie receivs a challenging case one day, when a small guinea pig comes in needing surgery to correct a serious heart conditionm. So, naturally, he asks Anthony for some help... even though Anthony is worried that his body might be too small for him to see properly. But, after gwtting some guidance from Maxwell, they decide to go through with the operation, where th guinea pig's life hangs in the balance.

Charlie and Anthony decide that it's time to return home to Rockport, and go back to living their normal lives.